<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2022-01-07T20:28:58.6381890+00:00 -->
<!-- Version            : 5.0.1.702 -->
<!-- Package ID         : 9d0fb66702924f678f7cbd9c22dee6f4 -->
<!-- Copyright (c) 2022 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="tlry_BrandsMember" name="BrandsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EquityInvestmentsUnderMeasurementAlternative" name="EquityInvestmentsUnderMeasurementAlternative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_DebtInstrumentMaturityYear" name="DebtInstrumentMaturityYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_MeasurementInputProbabilityOfConversionMember" name="MeasurementInputProbabilityOfConversionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputStrikePriceMember" name="MeasurementInputStrikePriceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputFairValueOfCommonStockMember" name="MeasurementInputFairValueOfCommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLineOfCredit" name="OperatingLineOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_EuroOverNightIndexAveragePlusMember" name="EuroOverNightIndexAveragePlusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusMember" name="EuroInterbankOfferedRatePlusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLinesOfCreditOneMember" name="OperatingLinesOfCreditOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLinesOfCreditTwoMember" name="OperatingLinesOfCreditTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLinesOfCreditThreeMember" name="OperatingLinesOfCreditThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CCPharmaMember" name="CCPharmaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FourTwentyCorporationMember" name="FourTwentyCorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EUROBIRRateMember" name="EUROBIRRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_NumberOfOperatingLinesOfCredit" name="NumberOfOperatingLinesOfCredit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CreditFacilityDueInNovemberTwoThousandTwentyTwoMember" name="CreditFacilityDueInNovemberTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInJulyTwoThousandTwentyThreeMember" name="TermLoanDueInJulyTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAprilTwoThousandTwentyTwoMember" name="TermLoanDueInAprilTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAugustTwoThousandTwentySixMember" name="TermLoanDueInAugustTwoThousandTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MortgagePayableDueInAugustTwoThousandTwentySixMember" name="MortgagePayableDueInAugustTwoThousandTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_VendorTakeBackMortgageDueInJuneTwoThousandTwentyOneMember" name="VendorTakeBackMortgageDueInJuneTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInDecemberTwoThousandTwentyThreeMember" name="TermLoanDueInDecemberTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAprilTwoThousandTwentyFiveMember" name="TermLoanDueInAprilTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInJuneTwoThousandTwentyFiveMember" name="TermLoanDueInJuneTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInMarchTwoThousandTwentyFourMember" name="TermLoanDueInMarchTwoThousandTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusOnePointSevenNinePercentageMember" name="EuroInterbankOfferedRatePlusOnePointSevenNinePercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusTwoPointSixEightPercentageMember" name="EuroInterbankOfferedRatePlusTwoPointSixEightPercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusTwoPointZeroZeroPercentageMember" name="EuroInterbankOfferedRatePlusTwoPointZeroZeroPercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtInstrumentAmortizationPeriod" name="DebtInstrumentAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CanadianPrimeInterestRateMember" name="CanadianPrimeInterestRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianFiveYearBondInterestRatePlusTwoPointSevenThreeMember" name="CanadianFiveYearBondInterestRatePlusTwoPointSevenThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtSettlement" name="DebtSettlement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_FivePointTwoFivePercentageContractualDebentureMember" name="FivePointTwoFivePercentageContractualDebentureMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtInstrumentConvertibleDescription" name="DebtInstrumentConvertibleDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_DebtInstrumentConvertibleMinimumThresholdPercentageDuringMeasurementPeriod" name="DebtInstrumentConvertibleMinimumThresholdPercentageDuringMeasurementPeriod" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_PercentageOfRedemptionValueOnPrincipalPlusAccruedAndUnpaidInterest" name="PercentageOfRedemptionValueOnPrincipalPlusAccruedAndUnpaidInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_EstimatedFairValueOfDebtPerConvertibleDebentures" name="EstimatedFairValueOfDebtPerConvertibleDebentures" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ConvertibleDebentureUnamortizedDiscount" name="ConvertibleDebentureUnamortizedDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ClassOfWarrantOrRightClassification" name="ClassOfWarrantOrRightClassification" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantIssued" name="ClassOfWarrantIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantOrRightExercisedOrExpired" name="ClassOfWarrantOrRightExercisedOrExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantExpiringSeptemberTwentySixTwoThousandTwentyOneMember" name="WarrantExpiringSeptemberTwentySixTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WarrantExpiringJanuaryThirtyTwoThousandTwentyTwoMember" name="WarrantExpiringJanuaryThirtyTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WarrantExpiringMarchSeventeenTwoThousandTwentyFiveMember" name="WarrantExpiringMarchSeventeenTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ClassOfWarrantOrRightExercised" name="ClassOfWarrantOrRightExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantCancelled" name="ClassOfWarrantCancelled" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantExpired" name="ClassOfWarrantExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantExercisedWeightedAveragePrice" name="ClassOfWarrantExercisedWeightedAveragePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantIssuedWeightedAveragePrice" name="ClassOfWarrantIssuedWeightedAveragePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantCancelledWeightedAveragePrice" name="ClassOfWarrantCancelledWeightedAveragePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantExpiredWeightedAveragePrice" name="ClassOfWarrantExpiredWeightedAveragePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_EstimatedFairValueOfWarrantLiabilityPerWarrant" name="EstimatedFairValueOfWarrantLiabilityPerWarrant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_SharebasedCompensationArrangementBySharebasedPaymentAwardStockOptionsSharesOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" name="SharebasedCompensationArrangementBySharebasedPaymentAwardStockOptionsSharesOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_PredecessorPlanMember" name="PredecessorPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_StockOptionsMember" name="StockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_UnrealizedLossOnAvailableForSaleDebtSecuritiesMember" name="UnrealizedLossOnAvailableForSaleDebtSecuritiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AphriaDiamondMember" name="AphriaDiamondMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AssetsLaibilittyNet" name="AssetsLaibilittyNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_CCPharmaNordicApSMember" name="CCPharmaNordicApSMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ColCannaSASMember" name="ColCannaSASMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OtherCommitmentDueAfterFourthYear" name="OtherCommitmentDueAfterFourthYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_LongTermDebtRepaymentMember" name="LongTermDebtRepaymentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleNotesPrincipalAndInterestMember" name="ConvertibleNotesPrincipalAndInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MaterialPurchaseObligationsMember" name="MaterialPurchaseObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConstructionCommitmentMember" name="ConstructionCommitmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_GuaranteedRoyaltyPaymentsTerminated" name="GuaranteedRoyaltyPaymentsTerminated" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_RoyaltyTerminationFee" name="RoyaltyTerminationFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_RoyaltyTerminationCashPayment" name="RoyaltyTerminationCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_RoyaltyTerminationSharesIssued" name="RoyaltyTerminationSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ABGIntermediateHoldings2LLCMember" name="ABGIntermediateHoldings2LLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ClassTwoCommonSharesMember" name="ClassTwoCommonSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLeaseLiabilityStatementsOfFinancialPositionExtensibleList" name="OperatingLeaseLiabilityStatementsOfFinancialPositionExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_FinanceLeaseLiabilityStatementsOfFinancialPositionExtensibleList" name="FinanceLeaseLiabilityStatementsOfFinancialPositionExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CannabisRevenueMember" name="CannabisRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisExciseTaxesMember" name="CannabisExciseTaxesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisRevenueNetMember" name="CannabisRevenueNetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholRevenueMember" name="BeverageAlcoholRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholExciseTaxesMember" name="BeverageAlcoholExciseTaxesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholRevenueNetMember" name="BeverageAlcoholRevenueNetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DistributionRevenueMember" name="DistributionRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WellnessRevenueMember" name="WellnessRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisCosts" name="CannabisCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_BeverageAlcoholCosts" name="BeverageAlcoholCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_DistributionCosts" name="DistributionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_WellnessCosts" name="WellnessCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_OfficeAndGeneralExpenses" name="OfficeAndGeneralExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_FairValueAdjustmentOfConvertibleDebenture" name="FairValueAdjustmentOfConvertibleDebenture" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_GainLossOnLongTermInvestments" name="GainLossOnLongTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_GainOnEquityInvestee" name="GainOnEquityInvestee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_APHATwentyFourConvertibleDebentureMember" name="APHATwentyFourConvertibleDebentureMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WarrantLiabilityMember" name="WarrantLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ContingentConsiderationsMember" name="ContingentConsiderationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtSecuritiesAvailableForSaleMember" name="DebtSecuritiesAvailableForSaleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtInstrumentsValuationTechniqueExtensibleList" name="DebtInstrumentsValuationTechniqueExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantsAndRightsOutstandingValuationTechniquesExtensibleList" name="WarrantsAndRightsOutstandingValuationTechniquesExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_DebtSecuritiesClassifiedUnderAvailableForSaleValuationTechniqueExtensibleList" name="DebtSecuritiesClassifiedUnderAvailableForSaleValuationTechniqueExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_MeasurementInputAchievementRateMember" name="MeasurementInputAchievementRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputInterestRateMember" name="MeasurementInputInterestRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MajorCustomersMember" name="MajorCustomersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WellnessBusinessMember" name="WellnessBusinessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianMedicalProductsMember" name="CanadianMedicalProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianAdultUseProductsMember" name="CanadianAdultUseProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WholesaleProductsMember" name="WholesaleProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_InternationalProductsMember" name="InternationalProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_RestOfWorldMember" name="RestOfWorldMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_NumberOfMajorCustomers" name="NumberOfMajorCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CommonClassTwoMember" name="CommonClassTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_SWAcquisitionMember" name="SWAcquisitionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BreckenridgeAcquisitionMember" name="BreckenridgeAcquisitionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FacilityAmendmentMember" name="FacilityAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BankOfMontrealMember" name="BankOfMontrealMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AlpineAcquisitionMember" name="AlpineAcquisitionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
